Antun Bačić, Željko Mimica
Use of 5HT3 antagonist - ondansetron in postoperative nausea and vomiting

The incidence of nausea and vomiting was studied in four groups of ASA I and ASA II state patients after cholecystectomia. Postoperative nausea and vomiting was recorded in 38,5% patients in the first group of 21 patients given halotane anesthesia. In the group on fentanyl anesthesia 55,5% had nausea and vomiting. The third group of 67 patients was given fentanyl anesthesia after which 58% (39) patients showed nausea and vomiting. Eighteen patients were givn placebo and 14 kept on vomiting (77%). Of 21 patients given 4 mg of ondansetron 16 (78%) stopped vomiting. Int he fourth group of 19 patients with earlier unpleasant experience of postoperative nausea and vomiting or suffering from kinetosis, 11 were given preoperatively 8 mg ondansetron and eight placebo. Seven patients (66%) given ondansetron did not have postoperative nausea and vomiting and 4 (34%) did. All eight patients given placebo showed postoperative nausea and vomiting.

Key words: postoperative vomiting, postoperative nausea, 5HT3 antagonist - ondansetron.