Dragan Ljutiĉ, Zvonko Rumboldt
Properties of pharmacokinetics and dosage of antibacterial drugs in renal failure

SUMMARY
As the most antibacterial drugs are removed through the kidneys, the knowledge of the pharmacokinetic properties of a particular drug in a normal renal function and its changes induced by kidney failure, are the most important prerequisites of rational pharmacotherapy. According to the mentioned baselines, in this article, pharmacokinetic properties (elimination, protein binding, half-life, volume of distribution) of rade frequently administered and available drugs, are showen. For practical purposes doses and dosage intervals, as well as their changes in a renal failure, are outlined.

Key words: antibacterial drugs, renal failure, pharmacokinetic properties.